Tinea unguium(adults):150–450 mg/week until nails are clear;(children): 6 mg/kg/week × 3–4 months (fingernails) or 5–7 months (toenails), or until nails are clear.
Common (≥1% of patients): rash, headache, dizziness, nausea, vomiting, abdominal pain, diarrhea, and/or elevated liver enzymes.
Infrequent (0.1–1% of patients): anorexia, fatigue, constipation.
Rare (<0.1% of patients): oliguria, hypokalaemia, paraesthesia, seizures, alopecia, Stevens–Johnson syndrome, thrombocytopenia, other blood dyscrasias, serious hepatotoxicity including liver failure, anaphylactic/anaphylactoid reactions.
Very rare: prolonged QT interval, torsades de pointes, ventricular tachycardia, cardiac arrest and sudden death have been noted.
High doses of fluconazole during the first trimester of pregnancy may be associated with a rare and distinct set of birth defects in infants.
Contraindications
Hypersensitivity to fluconazole.
Impaired liver or renal function.
Pregnancy.
Interactions
Fluconazole is contraindicated with erythromycin,cisapride, astemizole, pimozide, and quinidine, as well as terfenadine when dosing of fluconazole is 400 mg or greater.
Increased central nervous system depression: alfentanil, benzodiazepines, propoxyphene, buprenorphine, fentanyl.