Nicotinamide

Indications

• Prophylaxis and treatment of pellagra.
• Autoimmune bullous dermatoses ( pemphigoid, pemphigus, dermatitis herpetiformis, and linear IgA dermatosis).
• Bullous pemphigoid : 500 mg three times daily, start with 200–300 mg three times daily+ 500 mg tetracycline four times daily.
• Dietary supplement useful in acne vulgaris :Systemic nicotinamide+ azelaic acid, folic acid, copper, and pyridoxine.
• Ageing : topical niacinamide.
• Isoniazid-induced pellagra-like skin lesions.
• Hartnup disease :50–300 mg/day improves dermatologic and neurologic manifestations.
• Granuloma annulare : 500 mg TID.
• Actinic keratosis :500 mg twice daily to prevent new Aks.
• Wound healing.
• Sunscreen :Topical niacinamide.

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Dosage

• Standard dosage range : 300–500 mg TID.

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Monitoring

• Liver function tests in patients receiving long-term, high-dose therapy.

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Side effects

• Schizophrenia,with doses of 3–12 g daily.
• Headache and GI complaints.
• Hepatotoxicity(extremely rare).

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Pregnancy & Lactation

• Pregnancy category C.

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Drug info

• Nicotinamide is considered a very safe medication with few adverse effects.

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